Serotonin syndrome with fluoxetine plus tramadol

Serotonin syndrome associated with tramadol.

Tramadol Pill Alone May Cause Serotonin Syndrome

Correspondence To the Editor: Tramadol is a synthetic opioid analgesic chemically related to codeine and is classified as a Class II drug for the treatment of moderate intensity pain according to the WHO recommendation. Tramadol has low affinity for μ‑ and κ‑opioid receptors and inhibits the reuptake of both norepinephrine and serotonin (5‑hydroxytryptamine) neurotransmitters. It stimulates the...

Tramadol, Pharmacology, Side Effects, and Serotonin Syndrome: A Review.

BACKGROUND Serotonin syndrome is a mild to potentially life-threatening syndrome associated with excessive serotonergic activity within the central nervous system. Serotonin syndrome is associated with medication use, drug interactions, and overdose. While serotonin syndrome is often associated with the use of selective serotonin inhibitors (SSRI), an increasing number of reports are being pres...

Brain serotonin content regulates the manifestation of tramadol-induced seizures in rats: disparity between tramadol-induced seizure and serotonin syndrome.

BACKGROUND Tramadol-induced seizures might be pathologically associated with serotonin syndrome. Here, the authors investigated the relationship between serotonin and the seizure-inducing potential of tramadol. METHODS Two groups of rats received pretreatment to modulate brain levels of serotonin and one group was treated as a sham control (n = 6 per group). Serotonin modulation groups receiv...

Fluoxetine-Induced Atypical Serotonin Syndrome with Hallucinations Masquerading as a Parkinsonian Syndrome

Objective: To report a unique case of fluoxetine overdose leading to serotonin syndrome with auditory and complex visual hallucinations. This case also demonstrates serotonin syndrome may mimic a Parkinsonian syndrome, which is poorly described in the literature. Case Summary: A 65-year-old gentleman, undergoing evaluation for possible Parkinsonian syndrome with bradykinesia and rigidity presen...